Preparation of Orally Disintegrating Tablets with Taste-masking Function: Masking Effect in Granules Prepared with Correctives Using the Dry Granulation Method and Evaluation of Tablets Prepared Using the Taste-masked Granules
نویسندگان
چکیده
منابع مشابه
[Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcryst...
متن کاملFormulation and taste masking of Ranitidine orally disintegrating tablet
Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 seconds using super-disintegrants, special polymers, water soluble and even ...
متن کاملFormulation and taste masking of Ranitidine orally disintegrating tablet
Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 seconds using super-disintegrants, special polymers, water soluble and even ...
متن کامل[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods].
Many orally disintegrating tablets have recently been developed to improve oral ingestion and usability and are widely administered clinically, resulting in improved quality of life for patients. Since orally disintegrating tablets rapidly disintegrate in the mouth, the masking of unpleasant taste is important. We investigated the masking of the taste of furosemide (FU) as a model drug with cor...
متن کاملPreparation and evaluation of tablets rapidly disintegrating in saliva containing bitter-taste-masked granules by the compression method.
The aim of this study was to prepare, using taste-masked granules, tablets which can rapidly disintegrate in saliva (rapidly disintegrating tablet), of drugs with bitter taste (pirenzepine HCl or oxybutynin HCl). The taste-masked granules were prepared using aminoalkyl methacrylate copolymers (Eudragit E-100) by the extrusion method. None of the drugs dissolved from the granules (% of dissolved...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2010
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.130.81